The clinical guidelines for adult closed femoral shaft fractures, adult closed ankle fractures, and adult open tibial shaft fractures are specifically tailored to the needs of low- and middle-income countries (LMICs). These guidelines aim to improve patient outcomes, promote cost-effective care, and streamline the treatment of traumatic injuries. Developed by the AO Alliance in partnership with the College of Surgeons of East, Central, and Southern Africa (COSECSA) and the West African College of Surgeons (WACS), this initiative is designed to empower healthcare systems in LMICs to provide more effective, standardized care.